Understanding the molecular landscape of cancer has facilitated the development of diagnostic, prognostic, and predictive biomarkers for clinical oncology. Recent developments in the field of targeted therapies for cancer have added great demand for accurate, faster, and large-scale DNA sequencing technologies. Developments in next-generation DNA sequencing technologies have increased the speed and reduced the cost of sequencing the molecular information of cancer cells. This has unlocked opportunities to characterize the genomics and transcriptomic landscapes of cancer for translational research.
With a vision to define the future of cancer care in India, Triesta Sciences has facilitated numerous molecular diagnostic protocols for a broad spectrum of cancers.
Objectives:
- Adopt and contribute to an emerging medical discipline called “Genomic Medicine.”
- Implement genetic testing as the standard of care for treating cancer at an affordable cost for all patients through the usage of genomic data of patients for better diagnosis, making effective therapeutic decisions and achieving overall improved health outcomes.
- Help patients achieve longer, better life with improved outcomes
Services Offered:
a. Using Next Generation Sequencing (NGS)
- Somatic mutation testing of 523 genes in solid tumours.
- Somatic mutation testing of 72 genes in liquid malignancies.
- Germline mutation testing for inherited diseases in affected and unaffected individuals.
- HLA typing for mid and high resolution
b. Liquid Biopsy Services
- Circulating tumour cells (CTC) enumeration using Cell Search platform.
- Liquid biopsy for EGFR and KRAS by droplet digital PCR (ddPCR).
- Liquid biopsy in solid tumours by NGS.
USP:
- Dynamic team of scientists and pathologists with expertise in Molecular Biology, Genomics and Pathology to drive routine diagnostic tests.
- Committed to high quality lab work to release the reports before TAT.
- First lab to validate Comprehensive Gene Panel of 523 genes in solid tumors by NGS in India and second in Asia. Successfully tested and reported 1200 patient cases.
- First lab to validate Circulating tumor cells (CTC) enumeration on US FDA approved Cell Search Platform in India
- Pre and post genetic test counselling service for patients and family members
- Strong collaborative working relationships with Oncologists for clinical intervention.
- Effective integration of Genomics into clinical practice for better patient care and outcome
- Availability of well-annotated tissue biorepository
- Clinical data
Equipment:
- FDA approved platform for NGS (Next Gen Sequencing)
- Droplet Digital PCR
- FDA approved Cell Search Platform for Circulating Tumour Cells (CTC) Test
- Cell Search CTC (Circulating Tumour Cells) and Droplet Digital PCR
Most Frequently asked Tests
FAQ
How are genetic alterations passed down in families?
If an individual is identified to carry a genetic alteration, there is a 50% chance that it could be passed on to the next generation. Positive family history of cancer helps raising the red flag early to seek genetic consultation.
How can I identify if I have a risk for inheriting cancer?
Usually, the risk for inheriting cancer could be Identified by paying dose attention to your family history. Some of the red flags to watch out are:
- History of multiple family members or generations affected with the same or related cancers (For example: breast, ovarian, and prostate cancer).
- Multiple members on the same side of the family are affected with cancer (For example: maternal aunt with ovarian cancer, maternal cousin with breast cancer, maternal grandfather with prostate cancer).
- Cancer diagnosed at a younger than expected age.
- Bilateral cancers (both breast or both ovaries etc.)
- Specific ethnicity driven mutation, e.g., BRCA mutations in Ashkenazi Jews.
- High grade serous tumour histology/medullary Thyroid Cancer/ triple negative breast cancer.
Whom do I consult to understand my inherited cancer risk?
If you have a family history of cancer, or if you are anxious to know whether you or someone in your family is predisposed to developing· cancer, you should consult a Genetic Counselor. They are healthcare professionals with training in medical genetics & experienced in the area of inherited cancers, cancer risk assessment, testing, & counseling.
What should I expect during a genetic counseling session?
During a consultation, the genetic counselor will discuss and understand your personal or family history of cancer in order to assess your cancer risk. Based on this information, the counselor explains and guides you to choose the appropriate genetic test. provide information on cancer screening, prevention, and treatment options.
What is genetic testing? What cancers can be tested?
Genetic testing involves very simple saliva or blood-based tests. Results from a genetic test can be used to ascertain your cancer risk precisely. Genetic testing is available for many of the common cancers such as breast, ovarian, colon, prostate, and some of the rare cancer types.
What is genetic counseling?
A genetic consultation or counseling provides information, offers support, & addresses an individual's specific questions & concerns for various inherited conditions, including cancer. Genetic counseling for cancer involves having a trained genetic counselor or a clinical geneticist help you and your family understand Inherited cancer risk by discussing about your personal or family history of cancer.
What are the benefits of getting a genetic test done?
Genetic testing has become akin to knowing that certain abnormalities require careful monitoring, e.g. cholesterol levels or high blood pressure to prevent cardiac events. In inherited cancer, the alteration is in every cell so there can be no direct treatment. However, having this information allows us to closely monitor the individual, early detection, and timely management of cancer.
Most Common FAQs About Breast Cancer
What is the benefit of knowing my risk for developing breast cancer?
Understanding your risk will enable early diagnosis of breast - cancer/ Early diagnosis leads to early and successful treatment, helping the patients to continue and have a normal life span with a good quality of life.
Can men be affected if there is a history of breast cancer in the family?
Men do get breast cancer, although it is rare. However, if there Is a history of breast cancer (or any other form of cancer) in the family, there may be a genetic component predisposing man to other cancers. It Is best ruled out by talking to a genetic counselor and getting an appropriate test done if required.
Is every lump likely to be breast cancer?
8/10 lumps are usually benign; most lumps are not cancerous. However, it is best that appropriate screening tests are done to rule out breast cancer.
My mother has breast cancer. Will I get it?
Only 5-10% of cancers are inherited. Therefore, not all breast cancers are inherited. There may be an inherited form that runs in your family. The best way to know if you (or your siblings, aunts, children) are at risk is to consult a genetic counselor.
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